Lee Solomon Assistant Professor
Chemistry & Biochemistry Department
Welcome to the Solomon Group! Please look around and see the cool research being done in our lab. We are working at the interface of biology and chemistry to both understand natural function, but also to develop new technologies to improve people’s lives. For example, we are trying to develop artificial kinase proteins, which will teach us about these natural proteins and lead to interventions against a variety of diseases. Similarly, we are developing peptide-materials into life saving wound dressings that can help the body repair the damage faster and keep the wound free from microbes. These will also teach us about natural oxidoreductase proteins in nature.
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News & Views
Congratulations to Xia Parkes for Presenting her Poster at the Undergraduate Research Symposium here at Mason!
Congratulations to Majed for his publication: “Peptide PET Imaging: A Review of Recent Developments and a Look At The Future Of Radiometal-labeled Peptides in Medicine
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Congratulations to Chiranjit, Virginia, and the whole peptide amphiphile team for their paper: “Controlling heme redox properties in peptide amphiphile fibers with sequence and heme loading ratio”
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Congratulations to Jacklin for her paper Lambda CI binding to related phage operator sequences validates alignment algorithm and highlights the importance of overlooked bonds
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Alignment of major-groove hydrogen bond arrays uncovers shared information between different DNA sequences that bind the same protein
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Tailorable Tetrahelical Bundles as a Toolkit for Redox Studies
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Jacklin George
Jacklin George Proteins that bind DNA are vital and crucial for living organisms. Our research is basically concerned with designing proteins which will be used to target specific DNA sequences to either repress or induce specific function. In terms of DNA-binding protein design, we are enriching our basic knowledge of the nature of the DNA binding while revealing some hidden concepts of this binding nature.
Ralston Smith
Ralston Smith About my research: I am designing a granzyme B binding peptide that will ultimately serve as a PET imaging agent for the determination of cancer immunotherapy efficacy. The work I am doing involves in silico and in vitro experimentation to characterize the granzyme B binding of a few peptide variants. The intention of his project is to provide a highly accurate, non-invasive means of determining which patients will respond positively to cancer immunotherapy and which should seek out other therapies. Extracurriculars: In my free time, I enjoy playing video games, streaming series and movies, building Lego, and spending time with […]
Annie McAllister
My research is doing protein engineering, specifically de novo protein design to make a ribose binding protein. By combing computational work and wet lab experiential I hope to understand the fundamental forces behind ribose binding to better understand ATP binding as a whole. Outside of the lab I enjoy reading, playing videogames, and dying my hair.